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Tuesday 18 September 2007

Effect of antimicrobial compounds on Balamuthia mandrillaris encystment and human brain microvascular endothelial cell cytopathogenicity.

By: Siddiqui R, Matin A, Warhurst D, Stins M, Khan NA.

Antimicrob Agents Chemother 2007 Sep;(): [Epub ahead of print]

Cycloheximide, ketoconazole or pre-exposure of organisms to cytochalasin-D prevented Balamuthia mandrillaris-associated cytopathogenicity of human brain microvascular endothelial cells, which constitute the blood-brain barrier. In an assay for inhibition of cyst production, these 3 agents prevented the production of cysts suggesting that the biosynthesis of proteins and ergosterol and the polymerization of actin are important in cytopathogenicity and encystment.

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