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Friday 21 September 2007

Corneal ulcer due to Neocosmospora vasinfecta in an immunocompetent patient.

By: Manikandan P, Vismer HF, Kredics L, Dóczi I, Marasas WF, Bhaskar M, Anita R, Revathi R, Narendran V.

Med Mycol 2007 Sep;():1-6 [Epub ahead of print]

We report a case of Neocosmospora vasinfecta keratitis in a 55-year-old man. While the patient did not recall any specific trauma or eye injury, he might have sustained a trivial wound during the course of his duties as a farmer. Direct examination of corneal scrapings revealed fungal filaments. As topical treatment with natamycin and econazole and subsequent systemic ketoconazole therapy failed, a full thickness therapeutic keratoplasty was performed. Post-operative treatment with amphotericin B and clotrimazole combined with cyclosporine resulted in a complete cure. The residual corneal infiltration in the recipient cornea became clear in a week. The fungal isolate was initially identified as a Fusarium species, but later reidentified through the use of morphological characteristics and sequence analysis of the internal transcribed spacer region as N. vasinfecta. The latters is a Hypocrealean fungus not hitherto reported as a causative agent of keratomycosis.

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