Custom Search

News

Wednesday 01 December 1999

In vitro antifungal evaluation and studies on the mode of action of xanthoxyline derivatives.

By: Pinheiro TR, Yunes RA, Lopez SN, Santecchia CB, Zacchino SA, Cechinel Filho V.

Arzneimittelforschung 1999 Dec;49(12):1039-43

This study describes the fungistatic effect of xanthoxyline (CAS 90-24-4) and its derivatives against a panel of yeasts, filamentous fungi and dermatophytes, by using the agar dilution method. Results indicated that simple structural modifications led to more potent derivatives, especially in relation with dermatophytes. The most active compound tested (10), which is a benzenesulphonyl derivative, was 12-fold more potent than xanthoxyline itself against Trichophyton rubrum. The evaluation of the mode of action with the whole cell Neurospora crassa assay, suggested that some selected compounds may be acting by the inhibition of fungal cell-wall polymers synthesis or assembly.

Use of this site is subject to the following terms of use