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Saturday 01 September 2001

[Spondylodiscitis due to Histoplasma duboisii. Report of two cases and review of the literature]

By: N'dri Oka D, Varlet G, Kakou M, Zunon-Kipre Y, Broalet E, Ba Zeze V.

Neurochirurgie 2001 Sep;47(4):431-4

We report two cases of African histoplasmosis caused by Histoplasma duboisii located in the spine, on two Malian adults aged 40 and 47 years respectively. Clinical signs consisted of dorsal spinal syndrome in both cases and a paraplegia in one case. Radiography and CT scan revealed a spondylodiscitis without any bone reconstruction in both cases and a prevertebral abscess in one case. Diagnosis was confirmed by mycological and pathological examinations of surgical specimen which revealed Histoplasma duboisii fungus. Medical treatment, after surgical repair, consisted in ketoconazola with positive results after 12 months. This localisation is rare. It raises diagnosis problems with tuberculous spondylodiscitis because of their radio-clinical resemblance.

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