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Wednesday 01 August 2001

Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences.

By: Carroll ME, Campbell UC, Heideman P.

Exp Clin Psychopharmacol 2001 Aug;9(3):307-16

The effects of ketoconazole, an inhibitor of corticosterone synthesis, were examined during food satiation and food restriction in male and female rats to determine whether increases in heroin self-administration prompted by food restriction were due to a stress response. Females self-administered more heroin infusions than males under both feeding conditions. Food restriction increased heroin infusions by an average of 96% for both females and males. Ketoconazole suppressed the increase due to food restriction in females but not in males. Corticosterone reversed the effect of ketoconazole in a group of 8 females, suggesting an interaction between feeding conditions, sex, and the stress response in rats.

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