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Monday 09 February 2004

Synthesis and antifungal activities of phenylenedithioureas.

By: Phuong T, Khac-Minh T, Van Ha NT, Ngoc Phuong HT.

Bioorg Med Chem Lett 2004 Feb 9;14(3):653-6

A total of 20 new phenylenedithiourea derivatives was synthesized by reaction of phenylenediisothiocyanates with aromatic amines as aminobenzoic, aminosalicylic acid and their derivatives. Their chemical structures were confirmed by elemental analysis, IR spectrometry and 1H NMR. The compounds were screened for in vitro antifungal, antibacterial activities and some of them have strong antifungal activities comparable to the activity observed for ketoconazole.

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