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Thursday 28 February 2008

[Thymic carcinoid tumor revealed by a Cushing's syndrome: Usefulness of positron emission tomography.]

By: Gomard-Mennesson E, Sève P, De La Roche E, Collardeau-Frachon S, Lombard-Bohas C, Broussolle C.

Rev Med Interne 2008 Feb;(): [Epub ahead of print]

Ectopic adrenocorticotropic (ACTH) syndrome is a rare condition, generally due to lung or carcinoid tumors. 18-fluorodeoxy-glucose positron emission tomography ((18)FDG-PET) can be useful where conventional localization techniques often fail. A 50-year-old man presented with sudden diffuse oedema, hypokaliemic alkalosis, Diabetes mellitus and high serum levels of ACTH and cortisol. Ectopic ACTH syndrome was confirmed leading to ketoconazole treatment. Chest-computed tomography only revealed an aspecific anterior mediastinal nodule that was hypermetabolic on the whole body-(18)FDG-PET. A thymic tumor was suspected and the patient had a thymectomy that revealed an atypical carcinoid tumor with pleural carcinosis. The postoperative course was favorable with clinical and biochemical remission of neoplastic Cushing's syndrome.

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